Amaryl Generic (Glimepiride) is an oral medication used to treat type 2 (non-insulin-dependent) diabetes when diet and exercise alone fail to control abnormally high levels of blood sugar.

Like other diabetes drugs classified as sulfonylureas, Generic Amaryl lowers blood sugar by stimulating the pancreas to produce more insulin.

Generic Amaryl (Glimepiride) may be used with or without insulin. Type II diabetes is the most common type of diabetes that is found in 90% of patients with diabetes. In type II diabetes, insulin usually is not necessary to control the blood sugar. Instead, diet and oral medications often are sufficient. Intolerance to sugar that results in elevated blood sugar is caused by reduced insulin secretion by the pancreas and resistance to insulin's effects by the body's cells.

Amaryl Generic (Glimepiride) lowers the sugar level in the blood by stimulating insulin to be secreted from the pancreas into the blood. The pancreas must be capable of producing insulin for this medication to work. Insulin causes sugar to leave the blood and enter cells throughout the body.

Special information if you are pregnant or breastfeeding: Do not take Generic Amaryl while pregnant. Since studies suggest the importance of maintaining normal blood sugar levels during pregnancy, your doctor may prescribe injected insulin instead.

Most Important Fact about Generic Amaryl: Always remember that Generic Amaryl is an aid to, not a substitute for, good diet and exercise. Failure to follow a sound diet and exercise plan may diminish the results of Generic Amaryl and can lead to serious complications such as dangerously high or low blood sugar levels. Remember, too, that Generic Amaryl is not an oral form of insulin, and cannot be used in place of insulin.

Why should Generic Amaryl not be prescribed: Avoid Generic Amaryl if you have ever had an allergic reaction to it. Do not take Generic Amaryl to correct diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, and fruity breath). This condition should be treated with insulin.

Special warnings about Generic Amaryl: It's possible that drugs such as Generic Amaryl may lead to more heart problems than diet treatment alone, or treatment with diet and insulin. If you have a heart condition, you may want to discuss this with your doctor. When taking Amaryl Generic, you should check your blood and urine regularly for abnormally high sugar (glucose) levels. The effectiveness of any oral antidiabetic, including Amaryl, may decrease with time. This may occur because of either a diminished responsiveness to the medication or a worsening of the diabetes. Even people with well-controlled diabetes may find that stress such as injury, infection, surgery, or fever triggers a loss of control. If this happens, your doctor may recommend that you add insulin to your treatment with Amaryl or that you temporarily stop taking Amaryl and use insulin instead.

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